Optical Fluorescence Microscopy (Olympus BX43)
microParticles GmbH achieved breakthrough in the development of monodisperse flourescence-labelled silica particles
In order to respond to our customers’ increasing need for fluorescence labelled monodisperse silica particles, we have dedicated ourselves over the last months to intensive research and development on this field. In parallel were we able to achieve not only monodisperse nanoscale silica particles but also up to the range of 30 µm in diameter, equally fluorescently labelled.
One particular challenge was the development above 3µm in diameter since the availability in the market is restricted to fluorescently labelled silica particles with a broader diameter distribution, poor photostability and quick photo-bleaching, and in a limited spectral range.
Researchers from microParticles GmbH were now successful in solving this special challenge.
With this breakthrough a new generation of fluorescently labelled, monodisperse silica particles with high quality and variety is available to our customers.
The adjacent illustrations show a selection of monodisperse silica particles with blue, green, orange and red fluorescence.
The outstanding features of our new product line are:
- Monodisperse particle size distribution (CV < 5 %)
- Spherical shape
- Non-porous
- Strong fluorescence
- density 1,85 g/cm3
- Available in a wide spectral range (from blue through near-infrared (NIR))
- Fluorochromes are incorporated in the particle interior
- Applicable in aqueous media as well as in common organic solvents
- No dye leaching
- Mechanically robust
The application fields for the new products are: biomedical research and development, bioimaging, sensor technology, clinical diagnostics, photodynamic and/or photothermal therapeutic platforms (PDT/PTT), and others. Fluorescently labelled monodisperse silica particles will be available in all sizes as 2,5 % aqueous suspensions.